Multimeric antithrombotic agents
AssigneeDiatide, Inc.
InventorsRichard T. Dean, John Lister-James
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Abstract
This invention relates to antithrombotic agents and uses thereof. Specifically, the invention relates to chemical moieties that specifically bind to platelets and inhibit their aggregation, including linear and cyclic peptides. The invention provides methods for using these antithrombotic agents to prevent the formation of thrombi at sites in a mammalian body. In particular, the platelet-specific binding moieties including linear and cyclic peptides of the invention are covalently linked to a polyvalent linker moiety, so that the polyvalent linker moiety is covalently linked to a multiplicity of the platelet-specific binding moieties including linear and cyclic peptides. Effficacious antithrombotic agents are thereby provided.
Claims7
A multimeric antithrombotic agent comprising:
- (a) at least two copies of a platelet-binding moiety comprising a ligand for a platelet GPIIb/IIIa receptor;
- and
- (b) a polyvalent linking moiety which is covalently bonded to each platelet-binding moiety thereby linking the platelet-binding moieties;
- wherein said agent has a molecular weight of less than about 20,000 daltons.
Dependencies are inferred from the claim text.