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US 6,150,179 AGranted
Method of using solid state NMR to measure distances between nuclei in compounds attached to a surface
AssigneeCuraGen Corporation
InventorGregory T. Went
Life of this patent
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Abstract
The present method provides for a method of conducting solid state NMR distance measurements between nuclei in compounds attached to a surface. In specific embodiments the measurements are made by rotational echo double resonance (REDOR). Other embodiments are directed to the use of the method wherein the distances measurements involve peptides.
Claims20
A method for measuring one or more interatomic distances of a binder compound comprising measuring internuclear dipole-dipole interaction strengths between selected nuclei in a sample of the binder compound by means of solid state nuclear magnetic resonance, wherein:
- (i) said binder compound binds to a target compound, and
- (ii) said sample of the binder compound covalently is attached to the surface of a substrate during said step of measuring internuclear dipole-dipole interaction strengths, said substrate being different from said sample.
Dependencies are inferred from the claim text.