Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo
AssigneeThe Regents of the University of Michigan
InventorH. David Humes
Life of this patent
Estimating the term…
Abstract
A novel cell seeded hollow fiber bioreactor is described as a potential bioartificial kidney. Endothelial cells along with pericyte, vascular smooth muscle, and/or mesangial cells or any mesenchymally derived support cells are seeded along a hollow fiber in a perfused bioreactor to reproduce the ultrafiltration function and transport function of the kidney. Maintenance of tissue specific function and ultrastructure suggest that this bioreactor provides an economical device for treating renal failure.
Claims14
A bioartificial filtration device suitable for filtering blood comprising a bundle of semipermeable hollow fibers in a chamber defined by a housing having a perfusion inlet port, a perfusion outlet port and a blood filtrate outlet port, wherein said semipermeable hollow fibers are coated internally and/or externally with a first population of cells selected from the group consisting of nonimmortalized endothelial cells, epithelial cells, or a mixture thereof, and a second population of cells selected from the group consisting of pericytes, vascular smooth muscle cells, mesangial cells or a mixture thereof, wherein opposite ends of said bundle of semipermeable hollow fibers are connected to the perfusion inlet and outlet ports.
Dependencies are inferred from the claim text.