Methods for the diagnosis of glaucoma
AssigneeThe Regents of the University of California
InventorsThai D. Nguyen, Jon R. Polansky, Weidong Huang
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Abstract
A glucocorticoid-induced protein, TIGR, that is produced by cells of the trabecular meshwork can be used to diagnose glaucoma. The TIGR protein, anti-TIGR antibodies, and TIGR encoding sequences also provide a diagnostic for glaucoma and its related diseases.
Claims14
An isolated nucleic acid molecule that encodes a TIGR protein, wherein said nucleic acid molecule comprises the sequence of SEQ ID NO:3.
An isolated nucleic acid molecule that encodes a TIGR protein, wherein said nucleic acid molecule comprises the sequence of SEQ ID NO:2.
A cell containing an introduced nucleic acid molecule encoding a TIGR protein or fragment thereof, wherein said nucleic acid molecule comprises the sequence of SEQ ID NO:2, or progeny of said cell.
A cell containing an introduced nucleic acid molecule encoding a TIGR protein or fragment thereof, wherein said nucleic acid molecule comprises the sequence of SEQ ID NO:3, or progeny of said cell.
A cell containing a recombinant nucleic acid molecule encoding a TIGR protein or fragment thereof, wherein said nucleic acid molecule comprises the sequence of SEQ ID NO:2, or progeny of said cell.
A cell containing a recombinant nucleic acid molecule encoding a TIGR protein or fragment thereof, wherein said nucleic acid molecule comprises the sequence of SEQ ID NO:3, or progeny of said cell.
A cell containing a heterologous nucleic acid molecule encoding a TIGR protein or fragment thereof, wherein said nucleic acid molecule comprises the sequence of SEQ ID NO:2, or progeny of said cell.
A cell containing a heterologous nucleic acid molecule encoding a TIGR protein or fragment thereof, wherein said nucleic acid molecule comprises the sequence of SEQ ID NO:3, or progeny of said cell.
Dependencies are inferred from the claim text.