Biological array fabrication methods with reduction of static charge
AssigneeAffymetrix, Inc.
InventorsMartin J. Goldberg, Mel Yamamoto, Glenn H. McGall, Steven J. Woodman, Eric Spence, Lisa T. Kajisa
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Abstract
The present invention provides modified methods and apparatus for the preparation of arrays of material wherein each array includes a preselected collection of polymers, small molecules or inorganic materials associated with a surface of a substrate. The methods of the invention provide for modifications to general apparatus, flow cell geometries and solutions used in array fabrication.
Claims49
A method of fabricating an array comprising:
- fabricating materials on a surface of a substrate to form a biological array of materials;
- and
- removing static charge during said fabricating step.
A method of fabricating an array comprising:
- manipulating the static charge on a reactor;
- and fabricating materials using said reactor wherein said materials are organic compounds.
A method of fabricating an array comprising:
- fabricating materials on a surface of a substrate to form an array of organic materials, and;
- removing static charge during said fabrication step.
A method of fabricating an array comprising:
- fabricating materials on a surface of a substrate to form an array of materials wherein said materials are polymers comprising nucleic acids;
- and
- removing static charge during said fabrication step.
A method of fabricating an array comprising:
- fabricating materials on a surface of a substrate to form an array of organic polymer materials;
- and
- removing static charge during said fabrication step.
A method of fabricating an array comprising:
- reducing the static charge on a reactor and
- fabricating materials using said reactor where said materials are biological compounds.
A method of fabricating an array comprising:
- reducing the static charge on a reactor and
- fabricating materials using said reactor where said materials are organic polymers.
A method of fabricating an array comprising:
- reducing the static charge on a reactor and
- fabricating materials using said reactor where said materials are nucleic acids.
Dependencies are inferred from the claim text.