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AssigneesHeska Corporation, Colorado State University Research Foundation
InventorsRamaswamy Chandrashekar, Naotoshi Tsuji
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The present invention relates to: Dirofilaria and Brugia thioredoxin peroxidase type-2 (TPx-2) proteins; Dirofilaria and Brugia TPx-2 nucleic acid molecules, including those that encode such TPx-2 proteins; antibodies raised against such TPx-2 proteins; and compounds that inhibit Dirofilaria and Brugia TPx-2 activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
An isolated TPx-2 nucleic acid molecule selected from the group consisting of;
An isolated composition comprising an isolated TPx-2 nucleic acid molecule selected from the group consisting of;
A method to elicit an immune response, said method comprising administering to an animal an isolated composition comprising an isolated TPx-2 nucleic acid molecule selected from the group consisting of;
A method to produce a TPx-2 protein, said method comprising culturing in an effective medium a cell capable of expressing said protein, said protein being encoded by an isolated TPx-2 nucleic acid molecule selected from the group consisting of a Dirofilaria TPx-2 cDNA molecule;
Dependencies are inferred from the claim text.