Chemokine receptor able to bind to MCP-1, MIP-1.alpha. and/or RANTES. Its uses
AssigneeGlaxo Group Limited
InventorsTimothy N. C. Wells, Christine A. Power
Life of this patent
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Abstract
A chemokine receptor binds to MCP-1, MIP-1.alpha. and/or RANTES. It can be used in screening for agents which act as antagonists to MCP-1, MIP-1.alpha. and/or RANTES. Such agents may be useful in treating various disorders, including allergies, atheromas and diseases mediated by viruses. They may also be useful in preventing graft rejection and in protecting stem cells from potentially damaging effects of chemotherapy.
Claims18
A vector comprising a nucleic acid molecule that codes for a polypeptide wherein said polypeptide comprises the amino acid sequence shown in SEQ ID NO:20.
A host comprising a vector that comprises a nucleic acid molecule that codes for a polypeptide wherein said polypeptide comprises the amino acid sequence shown in SEQ ID NO:20.
An isolated nucleic acid that codes for a polypeptide wherein said polypeptide has the amino acid sequence shown in SEQ ID NO:20.
An isolated nucleic acid that has the nucleotide sequence shown in SEQ ID NO:19.
An isolated nucleic acid that comprises nucleotides 183-1262 of the nucleotide sequence shown in SEQ ID NO:19.
An isolated nucleic acid molecule that codes for a polypeptide wherein said polypeptide comprises the amino acid sequence shown in SEQ ID NO:6.
An isolated nucleic acid molecule that codes for a polypeptide wherein said polypeptide has the amino acid sequence shown in SEQ ID NO:6.
An isolated nucleic acid molecule that comprises the nucleotide sequence shown in SEQ ID NO:5.
An isolated nucleic acid molecule that has the nucleotide sequence shown in SEQ ID NO:5.
An isolated nucleic acid molecule that codes for a polypeptide wherein said polypeptide comprises the amino acid sequence shown in SEQ ID NO:20.
An isolated polypeptide that comprises the amino acid sequence shown in SEQ ID NO:20.
An isolated polypeptide that comprises the amino acid sequence shown in SEQ ID NO:6.
A method of identifying an agent which affects the interaction of a polypeptide comprising the amino acid sequence shown in SEQ ID NO:20 with RANTES, MIP-1.alpha. or MCP-1 wherein said method comprises assaying the binding of said agent to said polypeptide.
Dependencies are inferred from the claim text.