Reagents with enhanced performance in clinical diagnostic systems
AssigneeBayer Aktiengesellschaft
InventorLaura S. Uretsky
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Abstract
It has been found that imidazole and related buffers enhance the activity of certain preservatives, for example either (1) a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one or (2) 5-bromo-5-nitro-1,3-dioxane, that are used in clinical diagnostic reagents. It has also been found that these buffers and certain surfactants, such as Brij 700 and related hydrophilic surfactants, enhance the precision and accuracy of enzyme biosensors.
Claims17
A method of enhancing the antimicrobial activity of products comprising isothiazolines or nitrobromo compounds comprising the steps of:
- preparing a formulation comprising isothiazoline or a nitrobromo compound;
- and
- including in said formulation a buffer system comprising imidazole or monoalkyl derivatives thereof.
An antimicrobial system for clinical diagnostic reagents comprising (1) isothiazolines or nitrobromo compounds and (2) imidazole or monoalkyl derivatives thereof.
A method of enhancing the antimicrobial activity of products comprising isothiazolines or nitrobromo compounds by including in said products a buffer system comprising imidazole or 4-methyl imidazole.
An antimicrobial system for clinical diagnostic reagents comprising (1) isothiazolines or nitrobromo compounds and (2) imidazole or 4-methyl imidazole.
Dependencies are inferred from the claim text.