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US 6,150,119 AGranted
Optimized high-throughput analytical system
AssigneeCaliper Technologies Corp.
InventorsAnne R. Kopf-Sill, Andrea W. Chow
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Abstract
Throughput rates for microfluidic serial analysis systems are optimized by maximizing the proximity and speed with which multiple different samples may be serially introduced into a microfluidic channel network. Devices are included that include optimized parameters based upon desired throughput rates for a given set of reagents, reaction times and the like.
Claims22
A method of serially transporting a plurality of test compound plugs in a microfluidic channel, comprising:
- providing a microfluidic channel having a smallest cross-sectional dimension that is less than a maximum dimension d, where:
- ##EQU24## introducing a first test compound plug, where P is a period of time required to introduce the test compound plug into the channel, D is the diffusion coefficient of the test compound in the test compound plug, K is a proportionality factor, T is an amount of time for the test compound plug to move from introduction into the channel to a point of detection, and n is a ratio of initial plug length to average dispersion distance for the test compound in the test compound plug in time T, provided that T is greater than P;
- and
- introducing a second test compound plug into the channel after the first test compound plug.
1 more element
Dependencies are inferred from the claim text.