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US 6,150,109 AGranted
Lipophilic quenching of viral inactivating agents
AssigneeV. I. Technologies, Inc.
InventorsClark M. Edson, Andrei A. Purmal, Samuel K. Ackerman
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AssigneeV. I. Technologies, Inc.
InventorsClark M. Edson, Andrei A. Purmal, Samuel K. Ackerman
Estimating the term…
Methods and compositions for the inactivation and removal of contaminants of a biological composition are disclosed. The methods include the steps of: (a) contacting the biological composition with an inactivating agent including an aziridino moiety, such as ethyleneimine, an oligomer of ethyleneimine, or a haloderivative salt of either ethyleneimine or an oligomer of ethyleneimine, where a portion of the agent reacts with and inactivates the contaminant, and a portion of the agent remains unreacted; (b) contacting the product of step (a) with a lipophilic quenching agent including at least one quenching moiety attached to a lipophilic moiety, under conditions and for a time sufficient to allow the unreacted agent to bond covalently to the quenching moiety; and (c) separating the lipophilic quenching agent and the quenched inactivating agent from the biological composition.
A method of quenching an electrophile, said method comprising contacting said electrophile with a composition comprising at least one thiosulfate or thiophosphate moiety attached to a lipophilic moiety, under conditions and for a time sufficient to allow said electrophile to bond covalently to said thiosulfate or thiophosphate moiety.
A compound comprising (a) a lipophilic moiety;
Dependencies are inferred from the claim text.