Unique associated Kaposi's sarcoma virus sequences and uses thereof
AssigneeThe Trustees of Columbia University in the City of New York
InventorsYuan Chang, Patrick S. Moore
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Abstract
This invention provides an isolated DNA molecule which is at least 30 nucleotides in length and which uniquely defines a herpesvirus associated with Kaposi's sarcoma. This invention provides an isolated herpesvirus associated with Kaposi's sarcoma. This invention provides an antibody specific to the peptide. Antisense and triplex oligonucleotide molecules are also provided. This invention provides a method of vaccinating a subject for KS, prophylaxis diagnosing or treating a subject with KS and detecting expression of a DNA virus associated with Kaposi's sarcoma in a cell.
Claims24
An isolated nucleic acid which is at least 30 nucleotides in length and has a sequence which uniquely defines a herpesvirus associated with kaposi's sarcoma, which herpesvirus is present in and recoverable from the HBL-6 cell line (ATCC Accession No CRL 11762).
An isolated herpesvirus associated with kaposi's sarcoma which is present in and recoverable from the HBL-6 cell line (ATCC Accession No CRL 11762).
A nucleic acid of at least 14 nucleotides which hybridizes under high stringency conditions to at least a portion of a nucleotide sequence as shown in FIG. 3A (SEQ ID NO:1).
Dependencies are inferred from the claim text.