Preparation method for biodegradable polymeric microspheres using solvent extraction and preparation method for microspheres for treating local inflammation using the same
AssigneeKorea Institute of Science and Technology
InventorsSeo Young Jeong, Ick Chan Kwon, Yong-Hee Kim
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Abstract
A preparation method for biodegradable polymeric microspheres using a solvent extraction method for biodegradable polymeric microspheres for treating a local inflammation disease using the same which are capable of effectively curing ozena such as sinusitis and a middle ear infection. Since a non-solvent of polymer is added into an outer aqueous phase in advance, the solidification of the polymer is implemented in a short time which, in turn, improves encapsulation of the therapeutic agent used.
Claims2
A preparation method for a biodegradable polymeric microspheres for treating local inflammation disease, comprising:
- a step for preparing a W/O emulsion by mixing an inner aqueous phase containing water-soluble betalactam antibiotic agent and/or an inhibitor of betalactamase and an organic phase comprising an organic solvent of polymer in which a biodegradable polymer is dissolved, well dispersing the resulting emulsion;
- a step for preparing an outer aqueous phase wherein a non-solvent of the polymer is dissolved in an aqueous solution of distilled water containing a surface active agent;
- a step for adding the aforementioned W/O emulsion into the said outer aqueous phase to prepare a W/O/W emulsion;
- and
- a step for removing the organic solvent of the polymer.
Dependencies are inferred from the claim text.