Pharmaceutical pellet formulation

A method for the preparation of a pharmaceutical formulation with a core containing omeprazole in the form of its free base as the active ingredient, and an enteric coating, the core and, optionally, the coating contain TiO.sub.2, wherein initially a suspension I, containing a high proportion of omeprazole, is applied with adjuncts and TiO.sub.2 to starter cores, the high proportion of omeprazole in the suspension is then reduced continuously or batchwise by dilution of the suspension to be sprayed with a solution or suspension II of adjuncts, optionally with TiO.sub.2 to the point where the mixture of suspensions I and II to be applied contains practically no more omeprazole at the end of this process step, and the resulting pellets are then dried and provided with an enteric coating.

A method for the preparation of a pharmaceutical formulation with a core containing omeprazole in the form of its free base as the active ingredient, and an enteric coating, the core and, optionally, the coating containing TiO.sub.2, wherein a suspension I containing omeprazole is applied with adjuncts and TiO.sub.2 to starter cores, and the resulting pellets are then dried and a suspension II containing TiO.sub.2 is then applied, together with an enteric coating.