Taste of active pharmaceutical ingredients
AssigneeMerck Patent Gesellschaft mit
InventorsEugen Schwarz, Gernot Moschl, Siva Tallavajhala
Life of this patent
Estimating the term…
Abstract
The invention relates to a process for improving the taste of solid formulations containing one or more active ingredients.
Claims32
A method for improving the flavor profile of a solid formulation which comprises one or more active substances, comprising co-spray drying said active substance(s) and at least one polyol, wherein the polyol is dissolved in water, and the active substance(s) are dissolved or suspended in a solvent, and wherein the polyol is present in an amount effective to improve the flavor profile of the solid formulation.
A method for improving the flavor profile of a solid formulation which comprises one or more active substances, comprising subjecting said active substance(s) and at least one polyol to fluidized-bed granulation, thereby generating a form which can be directly compressed into a solid formulation, wherein the polyol is dissolved in water, and the active substance(s) are dissolved or suspended in a solvent, and wherein the polyol is present in an amount effective to improve the flavor profile of the solid formulation.
A method for improving the flavor profile of a solid formulation which comprises one or more active substances, consisting essentially of co-spray drying said active substance(s);
- at least one polyol;
- water;
- optionally another solvent;
- optionally one or more further flavor improvers;
- and optionally a color agent,
- wherein the polyol is dissolved in water and wherein the active substance(s) are dissolved or suspended in a solvent, and wherein the polyol is present in an amount effective to improve the flavor profile of the solid formulation.
Dependencies are inferred from the claim text.