Back to results
US 6,149,938 AGranted
Process for the preparation of a granulate suitable to the preparation of rapidly disintegrable mouth-soluble tablets and compositions obtained thereby
AssigneeElan Pharma International Limited
InventorsDaniele Bonadeo, Franco Ciccarello, Aberto Pagano
Life of this patent
Estimating the term…
Abstract
A process for making a granulate composition suitable to the preparation of an oral solid form that can disintegrate rapidly inside the buccal cavity is provided as well as the granulate compositions and obtained.
Claims8
A process for making a granulate for use in the preparation of mouth-soluble, rapidly disintegrating tablets, which process comprises:
- (i) granulating in a fluidized bed
- (a) a polyalcohol;
- (b) an active ingredient;
- (c) from 1 to 30% of an edible acid wherein the edible acid is not part of an effervescent mixture consisting of an acid and a base;
- (d) optionally, other solid components selected from the group consisting of lubricants, sweetening agents, and flavors;
- and
- (e) an aqueous solution or aqueous dispersion of a water-soluble or water-dispersible polymer that provides 1-10% of the final weight of the granulate;
- and
- (ii) drying the granulate in the fluidized bed.
6 more elements
Dependencies are inferred from the claim text.