Solid matrix system for transdermal drug delivery
AssigneeOrtho-McNeil Pharmaceutical, Inc.
InventorsChia-Ming Chiang, Renee Ann Tenzel
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Abstract
A matrix for containing drugs for transdermal delivery systems is disclosed. The matrix, formed of a skin-adhesive acrylate copolymer, attains high rates of drug delivery without the addition of drug delivery rate enhancers. In preferred embodiments the matrix is used to administer steroids, in particular estradiol. Water-soluble polymers may be added as well.
Claims21
A method for making an estrogen-containing matrix for use in a transdermal drug delivery device for administering at least one estrogen to an area of skin or mucosa, comprising the estrogen dispersed in a body of a pressure sensitive adhesive, the method comprising:
- a) incorporating an estrogen into a pressure sensitive adhesive material and a volatile solvent, to form a homogeneous solution or slurry;
- b) casting the homogeneous solution or slurry;
- and
- c) evaporating the volatile solvent from the homogeneous solution or slurry to form a solid matrix,
- wherein the pressure sensitive adhesive comprises an acrylate copolymer and polyvinylpyrrolidone, said matrix being essentially free of a skin permeation enhancer.
Dependencies are inferred from the claim text.