Methods and pharmaceutical compositions for the closure of retinal breaks
AssigneesThe Regents of the University of California, California Institute of Technology
InventorsDaniel M. Schwartz, Jeffrey A. Hubbell, Alexander R. Irvine
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Abstract
Described are compositions, methods, and articles of manufacture for the closure of retinal breaks with a non-toxic polymer. Transformation to a gel-like coat is achieved by photochemical reactivity, chemical reactivity, and by physicochemical response.
Claims53
A method for closing a retinal break in a mammal, comprising:
- applying over and around the retinal break a non-toxic polymer formulation comprising at least one polymer precursor that is a poly(ethylene glycol) (PEG) based polymer precursor, and transforming the polymer formulation into a gel-like coat.
A method for management of retinal detachment in a mammal, comprising:
- overlapping a retinal break with a non-toxic polymer formulation comprising at least one polymer precursor that is a poly(ethylene glycol) (PEG) based polymer precursor, and
- transforming the polymer formulation into a gel-like coat.
A method for preventing proliferative vitreoretinopathy in a mammalian eye having a retinal break, comprising:
- (a) applying over and around the retinal break and to more than about 50% of the retinal surface of the mammal a first solution comprising a non-toxic polymer formulation comprising at least one polymer precursor that is a poly(ethylene glycol) (PEG) based polymer precursor, and
- (b) transforming the polymer formulation into a gel-like coat.
A pharmaceutical composition for the closure of retinal breaks with a non-toxic, biodegradable polymer, comprising at least one photopolymerizable polymer precursor that is a poly(ethylene glycol) (PEG) based polymer precursor and at least one reagent that catalyzes photopolymerization of the precursor in admixture with a suitable vehicle for delivery to the interior of the eye.
An article of manufacture for the closure of retinal breaks with a non-toxic polymer comprising a first container comprising poly(ethylene glycol) (PEG) based polymer precursor of the formula:
- P.sub.m -D.sub.n -W.sub.o -D.sub.p -P.sub.q
- wherein W is a long chain PEG having a molecular weight of at least 8,000 g/mol;
- D is a degradable moiety;
- P is a photopolymerizable moiety;
- m and q are integers from 1 to about 10;
- o is an integer from 1 to about 100;
- and n and p are integers from 0 to about 120.
An article of manufacture for the closure of retinal breaks with a non-toxic polymer, comprising a first container comprising a first polymer precursor, a second container comprising a second polymer precursor that is a poly(ethylene glycol) (PEG) based polymer precursor, said first and second polymer precursors being mutually reactive.
Dependencies are inferred from the claim text.