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AssigneeCentro De Inmunologia Molecular
InventorsRolando Perez Rodriguez, Luis Enrique Fernandez Molina, Gilda Marquina Rodriguez, Adriana Carr Perez, Oscar Gonzalo Valiente Hernandez
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The invention provides novel uses for n-glycolylated gangliosides and N-acetylated gangliosides, or derivatives and/or oligosaccharides thereof The invention further provides methods of obtaining such gangliosides, as well as vaccine compositions comprising said gangliosides. The gangliosides may be coupled to carriers and may be accompanied by adjuvants. The vaccine compositions can be used in the treatment of breast cancers, whereby the gangliosides are used to elicit an immune response to corresponding gangliosides on breast tumor cells.
A vaccine composition for stimulating or increasing the antibody immune response against N-acetylated gangliosides comprising
A method of stimulating or increasing the immune response against N-acetylated gangliosides in a subject comprising the administration to said animal an immunogen selected from the group of immunogens consisting of N-acetylated gangliosides, the corresponding oligosaccharide, and mixtures thereof, coupled to a carrier protein comprising the OMPC of Neisseria meningitidis by non-covalent hydrophobic interaction and to an adjuvant.
Dependencies are inferred from the claim text.