Over-expressing homologous antigen vaccine and a method of making the same
AssigneesThe Regents of the University of California, Virginia Tech Intellectual Properties, Inc.
InventorsStephen M. Boyle, Silvio Cravero, Lynette Corbeil, Gerhardt Schurig, Nammalwar Srirnaganathan, Ramesh Vemulapalli
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Abstract
This invention relates to an over-expressing homologous antigen vaccine, a method of producing the same, and use of the vaccine for prophylaxis or treatment of vertebrates at risk of or suffering from disease caused by a pathogenic micro-organism. The vaccine is an attenuated or avirulent pathogenic micro-organism that over-expresses at least one homologous antigen encoded by at least one gene derived from the pathogenic micro-organism, and may also express a heterologous antigen.
Claims23
A vaccine for immunization, prophylaxis or treatment of a vertebrate at risk of or suffering from Brucellosis, wherein said vaccine comprises an attenuated or avirulent strain of an otherwise pathogenic bacteria of the genus Brucella, and wherein said strain over-expresses at least one homologous antigen encoded by at least one gene from said bacteria and wherein said at least one antigen is capable of inducing a protective or therapeutic immune response in the vertebrate against Brucellosis.
An attenuated or avirulent strain of B. abortus that over-expresses at least one homologous antigen encoded by at least one gene from said B. abortus, and wherein said at least one antigen is capable of stimulating a protective or therapeutic immune response against Brucellosis.
A method for immunization, prophylaxis or treatment of a vertebrate at risk of or suffering from Brucellosis comprising administering an effective amount of a vaccine, wherein said vaccine comprises an attenuated or avirulent strain of an otherwise pathogenic bacteria of the genus Brucella that over-expresses at least one homologous antigen encoded by at least one gene from said bacteria and wherein said at least one antigen is capable of inducing a protective or therapeutic immune response in the vertebrate against Brucellosis.
Dependencies are inferred from the claim text.