Treatment of diabetic nephropathy and microalbuminuria
AssigneeShiva Biomedical, LLC
InventorsHai-Ri Li, Hyun Chul Lee, Mankil Jung, Sudhir V. Shah
Life of this patent
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Abstract
Diabetic nephropathy and microalbuminuria are treated with the herb Salviae Miltiorrhizae Radix. In one embodiment, the method includes boiling the herb to form an aqueous extract. The aqueous extract is administered to the diabetic individual to treat diabetic nephropathy or to an individual exhibiting microalbuminuria. Alternatively the method can include administering a salt of lithospermic acid extracted from the herb. The method can include determining the level of protein in urine before, during and/or after administering the aqueous extract or a salt of lithospermic acid.
Claims52
A method of treating diabetic nephropathy in a diabetic individual comprising administering a Salviae Miltiorrhizae Radix herb, a Salviae Miltiorrhizae Radix mimic, or component thereof to the diabetic individual.
A method of treating diabetic nephropathy in a diabetic individual, comprising the steps of:
- a) forming an extract of a Salviae Miltiorrhizae Radix herb or a Salviae Miltiorrhizae Radix;
- and
- b) administering the extract to the diabetic individual.
A method of treating diabetic nephropathy in a diabetic individual, comprising the steps of:
- a) determining the level of protein in urine of the diabetic individual;
- b) comparing the level of protein in urine with a control level;
- and
- c) administering a Salviae Miltiorrhizae Radix herb, a Salviae Miltiorrhizae Radix mimic, or component thereof to the diabetic individual to lower the level of protein in urine of the diabetic individual to about that of the control level.
A method of treating diabetic nephropathy in a diabetic individual, comprising administering a salt of lithospermic acid to the diabetic individual.
A method of treating diabetic nephropathy in a diabetic individual, comprising the steps of:
- a) determining the level of protein in urine of the diabetic individual;
- b) comparing the level of protein in urine with a control level;
- and
- c) administering a salt of lithospermic acid to the diabetic individual to lower the level of protein in urine in the diabetic individual to about that of the control level.
A method of treating diabetic nephropathy in a diabetic individual comprising administering to the diabetic individual salt of lithospermic acid or a salt of lithospermic acid mimic.
A method of treating diabetic nephropathy in a noninsulin-dependent diabetic individual comprising administering a Salviae Miltiorrhizae Radix herb, a Salviae Miltiorrhizae Radix mimic, or component thereof, to the noninsulin-dependent diabetic individual.
A method of treating diabetic nephropathy in a noninsulin-dependent diabetic individual, comprising the steps of:
- a) forming an extract of a Salviae Miltiorrhizae Radix herb or a Salviae Miltiorrhizae Radix mimic to form an extract;
- and
- b) administering the extract to the noninsulin-dependent diabetic individual.
A method of treating diabetic nephropathy in a noninsulin-dependent diabetic individual, comprising the steps of:
- a) determining the level of protein in urine of the noninsulin-dependent diabetic individual;
- b) comparing the level of protein in urine with a control level;
- and
- c) administering a Salviae Miltiorrhizae Radix herb, or a Salviae Miltiorrhizae Radix mimic, or component thereof to lower the level of protein in urine of the noninsulin-dependent diabetic individual to about that of the control level.
A method of treating diabetic nephropathy in a noninsulin-dependent diabetic individual comprising administering a salt of lithospermic acid to the noninsulin-dependent diabetic individual.
A method of treating diabetic nephropathy in a noninsulin-dependent diabetic individual, comprising the steps of:
- a) determining the level of protein in urine of the noninsulin-dependent diabetic individual;
- b) comparing the level of protein in urine with a control level;
- and
- c) administering a salt of lithospermic acid to the noninsulin-dependent diabetic individual to lower the level of protein in urine of the noninsulin-dependent diabetic individual to about that of the control level.
A method of treating diabetic nephropathy in a noninsulin-dependent diabetic individual comprising administering to the noninsulin-dependent diabetic individual salt of lithospermic acid or a salt of lithospermic acid mimic.
A method of treating diabetic nephropathy in an insulin-dependent diabetic individual comprising administering to the insulin-dependent diabetic individual salt of lithospermic acid or a salt of lithospermic acid mimic.
A method of treating microalbuminuria in an individual comprising administering a Salviae Miltiorrhizae Radix herb, a Salviae Miltiorrhizae Radix mimic, or component thereof to the individual.
A method of treating microalbuminuria in an individual, comprising the steps of:
- a) forming an extract of a Salviae Miltiorrhizae Radix herb or a Salviae Miltiorrhizae Radix mimic;
- and
- b) administering the extract to the individual.
A method of treating microalbuminuria in an individual, comprising the steps of:
- a) determining the level of albumin in urine of the individual;
- b) comparing the level of albumin in urine with a control level;
- and
- c) administering a Salviae Miltiorrhizae Radix herb, a Salviae Miltiorrhizae Radix mimic, or component thereof to the individual to restore the level of albumin in urine in the individual to about that of the control level.
A method of treating microalbuminuria in an individual comprising administering a salt of lithospermic acid to the individual.
A method of treating microalbuminuria in an individual comprising administering salt of lithospermic acid to the individual.
A method of treating microalbuminuria in an individual, comprising the steps of:
- a) determining the level of albumin in urine of the individual;
- b) comparing the level of albumin in urine with a control level;
- and
- c) administering a salt of lithospermic acid to the individual to restore the level of albumin in urine in the individual to about that of the control level.
A method of treating microalbuminuria in an individual, comprising the steps of:
- a) determining the level of albumin in urine of the individual;
- b) comparing the level of albumin in urine with a control level;
- and
- c) administering salt of lithospermic acid to the individual to restore the level of albumin in urine in the individual to about that of the control level.
Dependencies are inferred from the claim text.