Peptides for the detection of HIV-1 group O
AssigneeOrtho-Clinical Diagnostics, Inc.
InventorsRobert De Leys, Jian Zheng
Life of this patent
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Abstract
This invention relates to peptides and their preparation. The peptides each have a sequence that corresponds to the immunodominant region of the HIV-1 group O gp41 envelope protein. The sequence is characterized in that it does not correspond to any known naturally occurring group O sequence or variant. Furthermore, the peptide binds anti-HIV-1 group O antibodies. There are several uses for the peptides, including the detection of antibodies produced in response to HIV-1 group O infection. The peptides may also be incorporated in mosaics and expressed recombinantly.
Claims3
A peptide comprising an amino acid sequence selected from the group consisting of
- SEQ ID NO:59 NQQRLNSWGCKGRIICYTSARWH, SEQ ID NO;61 EQQRLNSWGCKGRIICYTSARWH, SEQ ID NO:69 GRETLMQDQQRLNSWGCKGRIICYTSARWH, SEQ ID NO:60 XQQRLNSWGCKGRIICYTSARWH, SEQ ID NO:62 ETLMQXQQRLNSWGCKGRIICYTSARWH, SEQ ID NO:64 RARLQALETLMQNQQRLNSWGCKGRIICYTSARWH, and SEQ ID NO:65 DQQVNNVSSIIYDKILEAQDQQEENVRELLELD.
Dependencies are inferred from the claim text.