Metered dose inhaler for beclomethasone dipropionate
AssigneeGlaxoWellcome, Inc.
InventorIgnatius Loy Britto
Life of this patent
Estimating the term…
Abstract
A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising beclomethasone dipropionate or a physiologically acceptable solvate thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients.
Claims65
A metered dose inhaler having part or all of its internal surfaces coated with a polymer blend comprising one or more fluorocarbon polymers in combination with one or more non-fluorocarbon polymers, containing an inhalation drug formulation comprising beclomethasone dipropionate or a physiologically acceptable solvate thereof, and a fluorocarbon propellant.
A metered dose inhaler having part or all of its internal surfaces coated with a blend of a fluorinated polymer and a non-fluorinated polymer containing a drug formulation comprising beclomethasone dipropionate or a physiologically acceptable solvate thereof in the form of particles having a particle size less than 100 microns in an amount of 0.005 to 10% by weight relative to the total weight of the formulation and a fluorocarbon propellant which is 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoro-n-propane or a mixture thereof.
A metered dose inhaler, comprising:
- a can having a mouth, said can having on its internal surface a coating having a thickness of 1 .mu.m to 1 mm comprising a blend of a fluorinated polymer made from one or more monomeric units selected from the group consisting of tetrafluoroethylene, hexafluoropropylene, perfluoroalkoxyalkylene, and vinylidene fluoride and a non-fluorinated polymer selected from the group consisting of a polyamide, a polyimide, a polyamideimide, a polyethersulfone, a polyphenylene sulfide and an amine-formaldehyde thermosetting resin;
- a cap covering said mouth of said can;
- a drug metering value situated in said cap;
- and
- an inhalation drug formulation comprising 0.005 to 10% by weight of beclomethasone dipropionate or a physiologically acceptable solvate thereof relative to the total weight of said drug formulation, said beclomethasone dipropionate or a physiologically acceptable solvate thereof having a particle size less than 100 microns and a fluorocarbon propellant which is 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoro-n-propane or a mixture thereof.
A metered dose inhaler having all or part of its internal surfaces coated with a polymer blend consisting essentially of polytetrafluoroethylene and polyethersulfone and containing an inhalation drug formulation consisting essentially of beclomethasone dipropionate monohydrate and 1,1,1,2-tetrafluoroethane.
A metered dose inhaler having all or part of its internal surfaces coated with a polymer blend consisting essentially of polytetrafluoroethylene and polyethersulfone and containing an inhalation drug formulation consisting essentially of beclomethasone dipropionate monohydrate, 1,1,1,2-tetrafluoroethane and a polar cosolvent.
A metered dose inhaler having all or part of its internal surfaces coated with a polymer blend consisting essentially of polytetrafluoroethylene and polyethersulfone and containing an inhalation drug formulation consisting essentially of beclomethasone dipropionate monohydrate, 1,1,1,2-tetrafluoroethane and a surfactant.
A metered dose inhaler having all or part of its internal surfaces coated with a polymer blend consisting essentially of polytetrafluoroethylene and polyethersulfone and containing an inhalation drug formulation consisting essentially of beclomethasone dipropionate monohydrate, 1,1,1,2-tetrafluoroethane, a polar cosolvent and a surfactant.
A metered dose inhaler having all or part of its internal surfaces coated with a polymer blend consisting essentially of polytetrafluoroethylene and polyethersulfone and containing an inhalation drug formulation consisting essentially of beclomethasone dipropionate monohydrate and 1,1,1,2,3,3,3-heptafluoro-n-propane.
A metered dose inhaler having all or part of its internal surfaces coated with a polymer blend consisting essentially of polytetrafluoroethylene and polyethersulfone and containing an inhalation drug formulation consisting essentially of beclomethasone dipropionate monohydrate, 1,1,1,2,3,3,3-heptafluoro-n-propane and a polar cosolvent.
A metered dose inhaler having all or part of its internal surfaces coated with a polymer blend consisting essentially of polytetrafluoroethylene and polyethersulfone and containing an inhalation drug formulation consisting essentially of beclomethasone dipropionate monohydrate, 1,1,1,2,3,3,3-heptafluoro-n-propane and a surfactant.
A metered dose inhaler having all or part of its internal surfaces coated with a polymer blend consisting essentially of polytetrafluoroethylene and polyethersulfone and containing an inhalation drug formulation consisting essentially of beclomethasone dipropionate monohydrate, 1,1,1,2,3,3,3-heptafluoro-n-propane, a polar cosolvent and a surfactant.
A metered dose inhaler having all or part of its internal surfaces coated with a polymer blend consisting of polytetrafluoroethylene and polyethersulfone and containing an inhalation drug formulation consisting of beclomethasone dipropionate monohydrate and 1,1,1,2-tetrafluoroethane.
A metered dose inhaler having all or part of its internal surfaces coated with a polymer blend consisting of polytetrafluoroethylene and polyethersulfone and containing an inhalation drug formulation consisting of beclomethasone dipropionate monohydrate and 1,1,1,2,3,3,3-heptafluoro-n-propane.
Dependencies are inferred from the claim text.