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US 6,149,870 AGranted
Apparatus for in situ concentration and/or dilution of materials in microfluidic systems
AssigneeCaliper Technologies Corp.
InventorsJohn Wallace Parce, Anne R. Kopf-Sill
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Abstract
The present invention is generally directed to methods, apparatus and systems for use in performing in situ dilution or concentration of a particular subject material in a microfluidic device or system. These methods and apparatus may generally be integrated with other microfluidic operations and/or systems, to perform a number of different manipulations, wherein dilution or concentration, carried out within the context of the microfluidic device or system, is just one part.
Claims22
A microfluidic system for diluting a material in a microfluidic device, the system comprising:
- a microfluidic device having at least a first main channel disposed therein, said main channel having at least one microscale cross-sectional dimension;
- at least a first source of said material in fluid communication with said main channel at a first point along a length of said main channel;
- at least a first diluent source in fluid communication with said main channel at a second point along said length of said main channel;
- at least a first reservoir in fluid communication with said main channel at a third point along said length of said main channel;
- and
- a fluid direction system for delivering diluent and material to said main channel, and combining said diluent with said material to form first diluted material, and for transporting a portion of said first diluted material along said main channel.
3 more elements
Dependencies are inferred from the claim text.