Method and device for use in the diagnosis of inflammatory states in the urogenital tract
AssigneeAerocrine AB
InventorsKjell Alving, Jan M. Lundberg, Jon Lundberg, Eddie Weitzberg, Peter Wiklund
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Abstract
Device and method for collecting endogenous gaseous nitric oxide (NO), in the urogenital tract, for example in the urinary tract and in the uterus and oviducts. According to one embodiment, a NO permeable, liquid impermeable inflatable body (16) is positioned in the urethra (5) surrounded by the prostate gland (17), whereby an additional inflatable body (4) positioned in the bladder (2) serves to seal off the bladder from the urethra and helps in the positioning of the device. The present invention further relates to a method and a system for use in the diagnosis of inflammatory states in said organs.
Claims17
Device for localized collection of endogenous gaseous nitric oxide, characterized in that said device includes at least one inflatable body made of NO permeable and liquid impermeable material, at least one tube for inflation and sampling and means for inflating said body or bodies with a non reactive gas or gas mixture of known composition and aspiring and analysing the gas mixture or mixtures aspired.
Device according to any one of the previous claims, characterized in that said device comprises one or several inflatable bodies for anatomically positioning said device and sealing off neighbouring body cavities during sampling.
Method for collection of endogenous gaseous nitric oxide, produced in or on the surface of an urogenital organ, for example the urinary tract epithelium or the uterine or oviduct epithelium, characterized in that the endogenous gaseous nitric oxide is collected locally, from a defined inner cavity or a defined area on the epithelium on the inner or outer surface of such organ.
Method in the diagnosis of inflammatory conditions in the urogenital organs, characterized in that NO is measured in gas sampled from said organs and a found level being compared to the level for healthy individuals or with the level obtained at another occasion for the same individual.
Method in the diagnosis of inflammatory conditions in the urinary organs, preferably the bladder and urinary tract, characterized in that NO is measured in gas sampled from said organs and a found level being compared to the level for healthy individuals or with the level obtained at another occasion for the same individual.
Method in the diagnosis of inflammatory conditions in the genital organs, preferably the uterus and oviducts, characterized in that NO is measured in gas sampled from said organs and a found level being compared to the level for healthy individuals or with the level obtained at another occasion for the same individual.
System for use in the diagnosis of inflammatory conditions in the urogenital organs, comprising
- at least one body of NO permeable and liquid impermeable material,
- at least one fluid conduit connected to said;
- at least one body for inflation, sampling and purging,
- means for supplying a non reactive gas or gasmixture to said at least one body,
- means for aspiring the gas mixture in said at least one body,
- means for analyzing the composition of said, gas mixture, and
- means for displaying the results.
Dependencies are inferred from the claim text.