Targeted hysteresis hyperthermia as a method for treating tissue
AssigneeParagon Medical, Inc.
InventorsBruce Nathaniel Gray, Stephen Keith Jones
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Abstract
The present invention provides an improved method for treatment of diseased tissue, which comprises the steps of: (i) selecting at least a magnetic material which has a magnetic heating efficiency of at least about 4.5.times.10.sup.-8 J.m./A.g, when rotational magnetic field conditions are equal to or less than about 5.times.10.sup.8 A/m.s; (ii) delivering the magnetic material to a patient's diseased tissue; and (iii) exposing the magnetic material to a rotational magnetic field with a frequency of greater than about 10 kHz and a field strength selected such that the product of field strength, frequency and the radius of the exposed region is less than about 7.5.times.10.sup.7 A/s to generate hysteresis heat in the diseased tissue.
Claims47
A method for heating a substance, comprising the steps of:
- (i) inserting at least one magnetic material having a magnetic heating efficiency of at least about 4.5.times.10.sup.-8 J.m./A.g. when rotational magnetic field conditions are equal to or less than about 5.times.10.sup.8 A/s in the substance;
- and
- (ii) exposing the magnetic material to a rotational magnetic field with a frequency of greater than about 10 kHz and a field strength such that the product of field strength, frequency, and the radius of the exposed region is less than about 7.5.times.10.sup.7 A/s to generate hysteresis heat in the substance.
A method for treating biological tissue, comprising the steps of:
- (i) introducing at least one magnetic material which has a magnetic heating efficiency of at least about 4.5.times.10.sup.-8 J.m./A.g. when rotational magnetic field conditions are equal to or less than about 5.times.10.sup.8 A/s into the biological tissue;
- and
- (ii) exposing the magnetic material to a rotational magnetic field with a frequency of greater than about 10 kHz and a field strength selected such that the product of field strength, frequency, and the radius of the exposed region is less than about 7.5.times.10.sup.7 A/s to generate hysteresis heat in the tissue.
A method for generating hysteresis heat in a tissue, comprising:
- delivering to the tissue magnetic material having a magnetic heating efficiency of at least about 4.5.times.10.sup.-8 J.m./A.g., when the rotational magnetic field conditions are about 5.times.10.sup.8 A/s or less;
- and
- exposing the tissue, containing the delivered magnetic material, to a rotational magnetic field with a frequency of about 10 kHz or greater and a field strength such that the product of field strength, frequency, and the radius of the exposed tissue is less than about 7.5.times.10.sup.7 A/s to generate hysteresis heat in the tissue.
A method for the treatment of cancerous growth or tumors, comprising:
- delivering to a tissue containing a cancerous growth or tumor, a magnetic material having a magnetic heating efficiency of at least about 4.5.times.10.sup.-8 J.m./A.g., when the rotational magnetic field conditions are about 5.times.10.sup.8 A/s or less;
- and
- exposing the tissue, containing the delivered magnetic material, to a rotating magnetic field with a frequency of about 10 kHz or greater and a field strength such that the product of field strength, frequency, and the radius of the exposed tissue is less than about 7.5.times.10.sup.7 A/s to generate hysteresis heat in the tissue.
A composition comprising:
- a magnetic material having a magnetic heating efficiency of at least about 4.5.times.10.sup.-8 J.m./A.g., when the magnetic field conditions are about 5.times.10.sup.8 A/s or less;
- and
- a matrix-forming polymer;
- wherein the magnetic material is encapsulated in the polymeric matrix.
Dependencies are inferred from the claim text.