Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives

A compound having the formula:

• ##STR13## wherein:
• R.sub.1 -R.sub.6 may be the same or different and are H, alkyl or aralkyl having from
• 1 to 12 carbon atoms;
• m is an integer from 3 to 6, inclusive;
• n is an integer from 3 to 6, inclusive;
• excluding those compounds of formula (I) wherein all of R.sub.1 -R.sub.6 are H and further excluding those compounds of formula (I) wherein:
• 1) m is 3, n is 4, R.sub.1, R.sub.2, R.sub.5 and R.sub.6 are all H, and R.sub.3 and R.sub.4 are methyl;
• 2) m is 3, n is 4, R.sub.1 and R.sub.6 are methyl or ethyl, and R.sub.2 -R.sub.5 are all H;
• 3) m is 3, n is 4, and R.sub.1 -R.sub.6 are all methyl, ethyl or propyl;
• 4) m and n are 3, R.sub.1, R.sub.2, R.sub.5 and R.sub.6 are all H, and R.sub.3 and R.sub.4 are methyl;
• 5) m and n are 3 and R.sub.1 -R.sub.6 are all methyl;
• 6) m and n are 3, R.sub.1 and R.sub.6 are H, and R.sub.2 -R.sub.5 are all methyl;
• 7) m and n are 3, R.sub.1 and R.sub.6 are methyl, and R.sub.2 -R.sub.5 are all H;
• 8) m and n are 3, R.sub.1 and R.sub.6 are hydrogen, R.sub.2 and R.sub.5 are each ethyl and R.sub.3 and R.sub.4 are methyl;
• 9) m and n are 3, R.sub.1, R.sub.3, R.sub.4 and R.sub.6 are H an R.sub.1 --are each ethyl;
• 10) m and n are 4, and R.sub.1 -R.sub.6 are all methyl;
• 11) m and n are 4, R.sub.1, R.sub.3, R.sub.4 and R.sub.6 are H and R.sub.1 and R.sub.1 --are each ethyl;
• 12) R1-R6 are methyl, propyl, butyl, pentyl, benzyl are or .beta.,.beta.,.beta.-trifluoroethyl;
• or (II) a salt thereof with a pharmaceutically acceptable acid.