Preparation of sterol and stanol-esters
AssigneeMcNeil-PPC, Inc.
InventorJohn D. Higgins, III
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Abstract
The present invention provides a method for the direct esterification of stanols and sterols with fatty acids to form stanol/sterol-esters. The method provides a synthetic route that is amenable to large scale production of the esters in high yields. A preferred embodiment employs a food grade process free ot organic solvents or mineral acids.
Claims22
A method for producing stanol/sterol-esters comprising
- providing a stanol/sterol of the formula ##STR8## providing an acid, reacting said stanol/sterol and acid in the presence of a mild acid and catalyst resulting in the production of the subtantially discrete corresponding stanol/sterol ester of the formula ##STR9## wherein R.sub.1 is a carbon chain ranging from C.sub.6 -C.sub.23 ;
- and R.sub.2 is a carbon chain ranging from C.sub.3 -C.sub.15.
A method for producing stanol/sterol-esters comprising:
- providing a stanol/sterol of the formula ##STR10## providing a polyunsaturated fatty acid having from C.sub.6 to C.sub.24 carbon atoms in length;
- reacting said stanol/sterol and fatty acid in the presence of a mild acidic catalyst, resulting in the production of the substantially discrete corresponding stanol/sterol-ester.
A compound selected from the group consisting of ##STR11## and ##STR12## their isomers and mixtures thereof;
- wherein R.sub.2 is a carbon chain ranging from C.sub.3 -C.sub.15.
A compound selected from the group consisting of ##STR13## their isomers and mixtures thereof.
Dependencies are inferred from the claim text.