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AssigneeGreat Lakes Chemical Corporation
InventorsYuri Aleksandrovich Lapin, Ignacio H. Sanchez
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A water-scavenging solvent, such a polyphosphoric acid, can be used for the synthesis of cyclopentyl 2-thienyl ketone by the direct acylation of cyclopentanecarboxylic acid without first reacting the cyclopentanecarboxylic acid with thionylchloride to form the acid chloride, while achieving new and unexpected yields. A tiletamine-free base can be made from the cyclopentyl 2-thienyl ketone with a halide in the presence of a solvent for the cyclopentyl 2-thienyl ketone to form a halogenated cyclopentane 2-thienyl ketone, aminating the halogenated cyclopentane 2-thienyl ketone by reaction with an amine, and subjecting the reaction product to thermal rearrangement, in a suitable solvent, and at a sufficient temperature to form tiletamine free base. Each step for the formation of tiletamine free base can be accomplished using the same solvent, e.g., dichlorobenzene so that intermediates need not be isolated between reactions.
A method of reacting cyclopentanecarboxylic acid with thiophene to produce cyclopentyl 2-thienyl ketone comprising contacting the cyclopentanecarboxylic acid with thiophene in the presence of a water-scavenging solvent, in a weight ratio of water-scavenging solvent to thiophene of less than about 10:1.
A method of reacting cyclopentanecarboxylic acid with thiophene to produce cyclopentyl 2-thienyl ketone comprising contacting the cyclopentanecarboxylic acid with thiophene in the presence of a water-scavenging solvent.
A method of reacting cyclopentanecarboxylic acid with thiophene to produce cyclopentyl 2-thienyl ketone comprising contacting the cyclopentanecarboxylic acid with thiophene in the presence of a water-scavenging solvent and thereafter forming a tiletamine free base from the cyclopentyl 2-thienyl ketone by sequentially (a) contacting the cyclopentyl 2-thienyl ketone with a halide in the presence of a solvent for the cyclopentyl 2-thienyl ketone to form a halogenated cyclopentane 2-thienyl ketone;
Dependencies are inferred from the claim text.