Process to 5-methyleneoxazolines
AssigneeRohm and Haas Company
InventorsRenee Caroline Roemmele, Heather Lynnette Rayle
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Abstract
This invention provides a process for the preparation of a 5-methylene-1,3-oxazoline from an alkyl ketone by reacting the alkyl ketone with an acetylating agent and an acid catalyst in an appropriate solvent and at an appropriate temperature. The resulting 5-methylene-1,3-oxazoline can be chlorinated and subsequently hydrolyzed to form an .alpha.-chloroketone which is useful as a fungicide.
Claims21
A process for the preparation of a 2-substituted-4,4-disubstituted-5-methylene-1,3-oxazoline of formula (I) by cyclization of an alkyl ketone of formula (II) in the presence of an acetylating agent, an acid catalyst, an appropriate solvent or excess acetylating agent, and an appropriate reaction temperature ##STR11## wherein Z is alkyl or substituted alkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl,
- R is a hydrogen atom or alkyl, and
- R.sup.1 and R.sup.2 are each independently an alkyl or substituted alkyl group, or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached form a cyclic structure.
Dependencies are inferred from the claim text.