2-phenylpyridine derivative and production method thereof
AssigneeSumika Fine Chemicals Co., Ltd.
InventorsKozo Matsui, Kiyoshi Sugi, Yoshihide Umemoto, Tetsuya Shintaku, Nobushige Itaya
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AssigneeSumika Fine Chemicals Co., Ltd.
InventorsKozo Matsui, Kiyoshi Sugi, Yoshihide Umemoto, Tetsuya Shintaku, Nobushige Itaya
Estimating the term…
A series of compounds capable of deriving an intermediate for the production of a compound (A) of the following formula, ##STR1## which is an anti-HIV drug, and a production method thereof. To be specific, 4-(pyridin-2-yl)benzaldehyde hydrazone, a production method of this compound, and a production method from this compound to N-(tert-butoxycarbonyl)-N'-[4-(pyridin-2-yl)phenylmethyhidene]hydrazine. In addition, a salt of 2-(4-bromomethylphenyl)pyridine, 2-(4-dibromomethylphenyl)pyridine and a salt thereof, production methods of these compounds, and production methods to derive 4-(pyridin-2-yl)benzaldehyde which is a production intermediate for 4-(pyridin-2-yl)benzaldehyde hydrazone from these compounds.
A method for the production of N-(tert-butoxycarbonyl)-N'-[4-(pyridin-2-yl)phenyhmethylidene]hydrazine of the formula (VI) ##STR21## wherein tBu is tert-butyl, comprising reacting 4-(pyridin-2-yl)benzaldehyde hydrazone of the formula (V) ##STR22## with di-tert-butyl dicarbonate of the formula:
Dependencies are inferred from the claim text.