Amino acid derivatives, processes for the manufacture thereof and pharmaceutical compositions containing these compounds
AssigneeBoehringer Ingelheim GmbH
InventorsFranz Esser, Gerd Schnorrenberg, Horst Dollinger, Birgit Jung, Erich Burger
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Abstract
The invention relates to new amino acid derivatives of general formula I and the pharmaceutically acceptable salts thereof, wherein group B is --A.sup.2 --NR.sup.2 R.sup.3 or R.sup.5, wherein group R.sup.5 is ##STR1## and R.sup.1, A.sup.1, A.sup.2, R.sup.2, R.sup.3, R.sup.6, R.sup.7, R.sup.8, R.sup.9, X, Y, Z, t and u have the meanings described in the specification, as well as the preparation and use thereof. The novel compounds are valuable neurokinin (tachykinin) antagonists.
Claims3
A compound of formula ##STR355## wherein T is methyl or methoxy and Q is an arylalkanoyl selected from the group consisting of ##STR356## pharmaceutically acceptable salt thereof.
A compound of formula ##STR357## wherein T is methyl or methoxy and Q' is an alkanoyl selected from the group consisting of ##STR358## or a pharmaceutically acceptable salt thereof.
A compound of formula ##STR359## wherein T is methyl or methoxy and Q" is an aryloxyacetyl selected from the group consisting of ##STR360## or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.