Method for treating cyclic phosphate compound
AssigneeNovartis AG
InventorsOreste Ghisalba, Guy Joel Christian Marais, Pierre Martin
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Abstract
The invention relates to a compound of formula (I) ##STR1## Wherein: B is adenine, guanine or hypoxanthine Z is hydrogen or a negative charge R is --[CH.sub.2 CH(R.sup.1)--O].sub.n -R.sup.2, --CH.sub.2 CH.sub.2 X, in which R.sup.1 is hydrogen or (C.sub.1 -.sub.6) alkyl R.sup.2 is hydrogen or (C.sub.1 -.sub.6) alkyl n is a number from 1 to 6 X is OH, F, NR.sup.3 R.sup.4 R.sup.3 and R.sup.4 are independently from each other hydrogen or (C.sub.1 -.sub.6) alkyl and to methods of enzymatically treating these compounds with biocatalysts having cyclic phosphodiesterase activity.
Claims12
A method for enzymatically treating a compound comprising the step of:
- treating a compound of Formula (I) ##STR5## with a biocatalyst having cyclic phosphodiesterase activity wherein R is --[CH.sub.2 CH(R.sup.1)--O].sub.n -R.sup.2 or --CH.sub.2 CH.sub.2 X, and wherein R.sup.1 is hydrogen or (C.sub.1 -C.sub.6) alkyl, n is a number form 1 to 6, X is OH, F, NR.sup.3 R.sup.4, and R.sup.3 and R.sup.4 are independently from each other hydrogen or (C.sub.1 -C.sub.6) alkyl;
- B is adenine, guanine or hypoxanthine;
- and,
- Z is hydrogen or a negative charge,
- Wherein the source of the biocatalyst having cyclic phosphodiesterase activity is a gram-negative bacterium.
A method for preparing a compound comprising the step of:
- contacting a biocatalyst having cyclic phosphodiesterase activity with a compound of formula (I) ##STR8## wherein:
- B is adenine, guanine or hypoxanthine;
- Z is hydrogen or a negative charge;
- and
- R is --[CH.sub.2 CH(R.sup.1)--O].sub.n -R.sup.2 or --CH.sub.2 CH.sub.2 X, wherein
- R.sup.1 is hydrogen or (C.sub.1 -C.sub.6) alkyl,
- R.sub.2 is hydrogen or (C.sub.1 -C.sub.6) alkyl,
- n is a number from 1 to 6,
- X is OH, F, NR.sup.3 R.sup.4, and
- R.sup.3 and R.sup.4 are independently from each other hydrogen or (C.sub.1 -C.sub.6) alkyl to produce a compound of formula (II) ##STR9##
Dependencies are inferred from the claim text.