US 6,147,202 AGranted

Production of human hemoglobin in transgenic pigs

OwnerRamesh Kumar, Ajay Sharma +3inventors

InventorsRamesh Kumar, Ajay Sharma, Clara Paulhiac, Anastasia M. Khoury-Christianson, Sunita Midha

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Abstract

The present invention relates to the use of transgenic pigs for the production of human hemoglobin. The transgenic pigs of the invention may be used as an efficient and economical source of cell-free human hemoglobin that may be used for transfusions and other medical applications in humans.

Claims1

Dependent claims

A purified and isolated nucleic acid comprising the sequence as set forth in SEQ. ID NO:

Dependencies are inferred from the claim text.

Facts

Application: 09/138,922Filed 24 Aug 1998 · continuation
Priority: 14 Jun 1991
Granted: 14 Nov 2000
Term ends: Not estimatedThe source records don’t support an estimate.

Classification14 codes

C12N 15/8509
For animal cells: for producing genetically modified animals, e.g. transgenic
A01K 67/0275
New or modified breeds of vertebrates: genetically modified vertebrates, e.g. transgenic
A01K 67/0278
Genetically modified vertebrates, e.g. transgenic: knock-in vertebrates, e.g. humanised vertebrates
C07K 14/805
Porphyrin- or corrin-ring-containing peptides: haemoglobins; Myoglobins

Family

Serial717,774Parent of this continuation-in-part · filed 14 Jun 1991
Serial897,648Parent of this continuation-in-part · filed 12 Jun 1992
Serial030,897Parent of this continuation-in-part · filed 15 Mar 1993
Serial105,989Parent of this continuation · filed 11 Aug 1993
US 5,922,854 AParent of this continuation
US 6,147,202 AThis patent

From the US filing history. Foreign family members aren’t listed.

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