Tub interactor (TI) polypeptides and uses therefor
AssigneeMillennium Pharmaceuticals, Inc.
InventorsCarlos J. Gimeno, Patrick R. Errada
Life of this patent
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Abstract
The present invention provides a novel tub interactor (TI) polypeptides, as well as TI fusion polypeptides, and antigenic peptides.
Claims41
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:31.
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:32.
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:33.
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:34.
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:35.
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:36.
An isolated polypeptide consisting of the amino acid sequence of SEQ ID NO:31.
An isolated polypeptide consisting of the amino acid sequence of SEQ ID NO:32.
An isolated polypeptide consisting of the amino acid sequence of SEQ ID NO:33.
An isolated polypeptide consisting of the amino acid sequence of SEQ ID NO:34.
An isolated polypeptide consisting of the amino acid sequence of SEQ ID NO:35.
An isolated polypeptide consisting of the amino acid sequence of SEQ ID NO:36.
An isolated polypeptide comprising an amino acid sequence encoded by the nucleotide sequence of the DNA insert of the plasmid deposited with ATCC as Accession Number 98125.
An isolated polypeptide comprising an amino acid sequence encoded by the nucleotide sequence of the DNA insert of the plasmid deposited with ATCC as Accession Number 98126.
An isolated polypeptide comprising an amino acid sequence encoded by the nucleotide sequence of the DNA insert of the plasmid deposited with ATCC as Accession Number 98127.
An isolated polypeptide comprising an amino acid sequence encoded by the nucleotide sequence of the DNA insert of the plasmid deposited with ATCC as Accession Number 98128.
An isolated naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:31, wherein the naturally occurring allelic variant is encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:1, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 65.degree. C.
An isolated naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:32, wherein the naturally occurring allelic variant is encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:2, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 65.degree. C.
An isolated naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:33, wherein the naturally occurring allelic variant is encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:3, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 65.degree. C.
An isolated naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:34, wherein the naturally occurring allelic variant is encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:4, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 65.degree. C.
An isolated naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:35, wherein the naturally occurring allelic variant is encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:5, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 65.degree. C.
An isolated naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:36, wherein the naturally occurring allelic variant is encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:6, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 65.degree. C.
An isolated naturally occurring allelic variant of a polypeptide consisting of the amino acid sequence of SEQ ID NO:31, wherein the naturally occurring allelic variant is encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:1, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 65.degree. C.
An isolated naturally occurring allelic variant of a polypeptide consisting of the amino acid sequence of SEQ ID NO:32, wherein the naturally occurring allelic variant is encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:2, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 65.degree. C.
An isolated naturally occurring allelic variant of a polypeptide consisting of the amino acid sequence of SEQ ID NO:33, wherein the naturally occurring allelic variant is encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:3, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 65.degree. C.
An isolated naturally occurring allelic variant of a polypeptide consisting of the amino acid sequence of SEQ ID NO:34, wherein the naturally occurring allelic variant is encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:4, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 65.degree. C.
An isolated naturally occurring allelic variant of a polypeptide consisting of the amino acid sequence of SEQ ID NO:35, wherein the naturally occurring allelic variant is encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:5, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 65.degree. C.
An isolated naturally occurring allelic variant of a polypeptide consisting of the amino acid sequence of SEQ ID NO:36, wherein the naturally occurring allelic variant is encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:6, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 65.degree. C.
An isolated naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:31, wherein the naturally occurring allelic variant is encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:1, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 65.degree. C., wherein the naturally occurring allelic variant binds a Tub interactor protein.
An isolated naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:32, wherein the naturally occurring allelic variant is encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:2, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 65.degree. C., wherein the naturally occurring allelic variant binds a Tub interactor protein.
An isolated naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:33, wherein the naturally occurring allelic variant is encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:3, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 65.degree. C., wherein the naturally occurring allelic variant binds a Tub interactor protein.
An isolated naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:34, wherein the naturally occurring allelic variant is encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:4, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 65.degree. C., wherein the naturally occurring allelic variant binds a Tub interactor protein.
An isolated naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:35, wherein the naturally occurring allelic variant is encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:5, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 65.degree. C., wherein thc naturally occurring allelic variant binds a Tub interactor protein.
An isolated naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:36, wherein the naturally occurring allelic variant is encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:6, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 65.degree. C., wherein the naturally occurring allelic variant binds a Tub interactor protein.
An isolated Tub interactor binding polypeptide encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:1, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 50-65.degree. C.
An isolated Tub interactor binding polypeptide encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:2, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 50-65.degree. C.
An isolated Tub interactor binding polypeptide encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:3, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 50-65.degree. C.
An isolated Tub interactor binding polypeptide encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:4, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 50-65.degree. C.
An isolated Tub interactor binding polypeptide encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:5, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 50-65.degree. C.
An isolated Tub interactor binding polypeptide encoded by a nucleic acid molecule which hybridizes to a complement of a nucleic acid molecule consisting of SEQ ID NO:6, in 6.times.SSC at 45.degree. C., followed by one or more washes in 0.2.times.SSC, 0.1% SDS at 50-65.degree. C.
Dependencies are inferred from the claim text.