Parathyroid hormone-related peptide analogs
AssigneeThe General Hospital Corporation
InventorsThomas J. Gardella, Harald Juppner
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Abstract
The present invention relates to novel PTHrP analogs that have been converted into potent PTH-2 receptor agonists or antagonists by the substitution of one or more amino acid residues of PTHrP to the corresponding residue(s) of PTH. A method of treating various disease states associated with altered function of the PTH-2 receptor, using these PTHrP analogs, is also described.
Claims6
A PTHrP of SEQ ID NO:2 that is a PTH-2 receptor agonist, as well as a PTH/PTHrP receptor agonist, wherein the amino acid sequence is altered at amino acid residues 5 and 23.
The PTHrP of SEQ ID NO:2 with the following modifications:
- (Ile.sup.5, Trp.sup.23)PTHrP-(1-36).
A PTHrP of SEQ ID NO:2 that is a PTH-2 receptor selective antagonist, as well as a PTH/PTHrP receptor agonist, wherein the amino acid sequence is altered at amino acid residue 23.
The PTHrP of SEQ ID NO:2 with the following modification:
- (Trp.sup.23)PTHrP-(1-36).
Dependencies are inferred from the claim text.