Back to results
US 6,147,087 AGranted
Use of 1,2-Bridged 1,4-dihydropyridines as medicaments
AssigneeBayer Aktiengesellschaft
InventorsKlaus Urbahns, Hans-Georg Heine, Bodo Junge, Thomas Glaser, Reilinde Wittka, Jean-Marie-Viktor De Vry, Henning Sommermeyer
Life of this patent
Estimating the term…
Abstract
The present invention relates to the new use of 1,2-bridged 1,4-dihydropyridines which are known in some cases, of the general formula (I) ##STR1## in which R.sup.1 to R.sup.4 and a have the meaning indicated in the description, processes for their preparation and their use as medicaments, as selective potassium channel modulators, in particular for the treatment of the central nervous system.
Claims3
A 1,2-bridged 1,4-dihydropyridine of the formula ##STR18## in which
- ______________________________________ R.sup.1 R.sup.2 a R.sup.3 R.sup.4 ______________________________________ o,m--Cl--C.sub.6 H.sub.3 OCH.sub.3 1 --CH.sub.3 -- CH.sub.3 p--Cl--C.sub.6 H.sub.4 OCH.sub.3 1 --CH.sub.3 -- CH.sub.3 p--NO.sub.2 --C.sub.6 H.sub.4 CH.sub.3 1 CH.sub.3 -- CH.sub.3 m,p--Cl--C.sub.6 H.sub.3 CH.sub.3 1 CH.sub.3 -- CH.sub.3 o,m--Cl--C.sub.6 H.sub.3 CH.sub.3 1 CH.sub.3 -- CH.sub.3 p--CF.sub.3 --C.sub.6 H.sub.4 CH.sub.3 1 CH.sub.3 -- CH.sub.3 m--CF.sub.3, p--Cl--C.sub.6 H.sub.3 CH.sub.3 1 CH.sub.3 -- CH.sub.3 o,m--Cl--C.sub.6 H.sub.3 OCH.sub.3 1 OCH.sub.3 -- CH.sub.3 p--CF.sub.3 --C.sub.6 H.sub.4 OCH.sub.3 1 OCH.sub.3 -- CH.sub.3 p--Cl--C.sub.6 H.sub.4 OCH.sub.3 2 OCH.sub.3 -- CH.sub.3 p--Cl--C.sub.6 H.sub.4 OCH.sub.3 1 OCH.sub.3 -- CH.sub.3 ______________________________________
Dependencies are inferred from the claim text.