Inhibitors of p38

A compound of the formula:

• ##STR55## wherein:
• each of Q.sub.1 and Q.sub.2 are independently selected from phenyl, 5-6 membered aromatic heterocyclic ring systems, wherein each of said heterocyclic rings has a single nitrogen heteroatom;
• Q.sub.1 is substituted with 1 to 4 substituents, independently selected from halo;
• C.sub.1 -C.sub.3 alkyl;
• C.sub.1 -C.sub.3 alkyl substituted with NR'.sub.2, OR', CO.sub.2 R' or CONR'.sub.2 ;
• O--(C.sub.1 -C.sub.3)-alkyl;
• O--(C.sub.1 -C.sub.3)-alkyl substituted with NR'.sub.2, OR', CO.sub.2 R' or CONR'.sub.2 ;
• NR'.sub.2 ;
• OCF.sub.3 ;
• CF.sub.3 ;
• NO.sub.2 ;
• CO.sub.2 R';
• CONR';
• SR';
• S(O.sub.2)N(R').sub.2 ;
• SCF.sub.3 ;
• or CN;
• and
• Q.sub.2 is optionally substituted with up to 4 substituents, independently selected from halo;
• C.sub.1 -C.sub.3 straight or branched alkyl;
• C.sub.1 -C.sub.3 straight or branched alkyl substituted with NR', NR'.sub.2, OR', CO.sub.2 R', or CONR'.sub.2 ;
• O--(C.sub.1 -C.sub.3)-alkyl;
• O--(C.sub.1 -C.sub.3)-alkyl substituted with NR', NR'.sub.2, OR', CO.sub.2 R' or CONR'.sub.2 ;
• NR'.sub.2 ;
• OCF.sub.3 ;
• CF.sub.3 ;
• NO.sub.2 ;
• CO.sub.2 R';
• CONR';
• R.sup.3 ;
• OR.sup.3 ;
• NR.sup.3 ;
• SR.sup.3 ;
• C(O)R.sup.3 ;
• C(O)N(R')R.sup.3 ;
• C(O)OR.sup.3 ;
• SR';
• S(O.sub.2)N(R').sub.2 ;
• SCF.sub.3 ;
• or CN;
• wherein R' is selected from hydrogen, (C.sub.1 -C.sub.3)-alkyl or (C.sub.2 -C.sub.3)-alkenyl or alkynyl;
• and
• R.sup.3 is selected from phenyl, --(CH.sub.2).sub.m --W or W, wherein m is 1, 2, or 3;
• X is selected from --S--, --O--, --S(O.sub.2)--, --S(O)--, [--S(O.sub.2)--N(R)--, --N(R)--S(O.sub.2)--, --N(R)--C(O)O--, --O--C(O)--N(R),] --C(O)--, [--C(O)O--, --O--C(O)--, --C(O)--N(R)--, --N(R)--C(O)--,] --N(R)--, or --C(R).sub.2 --;
• each R is independently selected from hydrogen or (C1-C3)-alkyl;
• W is selected from --N(R').sub.2, --OR', --SR', --S(O)R', --S(O.sub.2)R', C(O)OR', ##STR56## or any 5 to 6-membered saturated or unsaturated heterocyclic ring having up to 2 nitrogen heteroatoms, wherein said heterocyclic ring is optionally substituted with up to 3 substituents independently selected from halo, C.sub.1 -C.sub.3 alkyl, O--(C.sub.1 -C.sub.3)-alkyl, NR'.sub.2, OCF.sub.3, CF.sub.3, NO.sub.2, CO.sub.2 R', CONR' or CN;
• Y is C;
• A is CR';
• n is 1;
• and
• R.sub.1 is selected from hydrogen, (C.sub.1 -C.sub.3)-alkyl, OH, or O--(C.sub.1 -C.sub.3)-alkyl.