Methods and compositions for controlling iron stores to treat and cure disease states
OwnerFrancesco Facchiniinventor
Life of this patent
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Abstract
Methods and compositions of matter are provided that enable a phased reduction of body iron stores to near a iron deficiency level, and thereafter maintain the body iron stores at that level by reducing further iron accumulation. In a first phase, a patient's body iron stores are reduced to a level of near iron deficiency by regular periodic phlebotomy or use of pharmacological agents, such as iron chelators, for example, over a period of six to twelve months. In a second phase, ingested iron absorption is controlled using an oral dose, taken at mealtimes, of compound comprising a calcium salt and salts of phytic acid, without or without zinc, or by continuing, less frequent phlebotomy.
Claims31
A method of reducing and maintaining body iron stores of a patient to a near-iron deficiency level comprising:
- during a first phase of treatment, reducing iron body stores to a near-iron deficiency level corresponding to a serum ferritin level less than about 40 ng/ml and an iron saturation index less than about 15%;
- and
- during a second phase of treatment, maintaining iron body stores at the near-iron deficiency level.
A method of reducing and maintaining body iron stores of a patient to a near-iron deficiency level to alleviate symptoms of non-insulin dependent diabetes mellitus, primary hypertension and cardiovascular disease, the method comprising:
- reducing body iron stores to a near-iron deficiency level corresponding to a serum ferritin level less than about 40 ng/ml and an iron saturation index less than about 15%;
- and
- administering to the patient an oral dose of an iron binding compound in an amount effective to inhibit intestinal iron absorption to maintain body iron stores at the near-iron deficiency level.
A method of controlling body iron stores of a patient at a near-iron deficiency level comprising:
- monitoring body iron stores by periodically testing the patient's blood to measure a serum ferritin level and an iron saturation level;
- and
- ingesting a sufficient oral dose of an iron binding compound on a daily basis to inhibit intestinal iron absorption and maintain body iron stores at a near-iron deficiency level corresponding to a serum ferritin level less than about 40 ng/ml and an iron saturation index less than about 15%.
A method of controlling body iron stores of a patient at a near-iron deficiency level to alleviate symptoms of non-insulin dependent diabetes mellitus, primary hypertension and cardiovascular disease, the method comprising:
- monitoring body iron stores by periodically testing the patient's blood to measure a serum ferritin level and an iron saturation level;
- and
- administering to the patient an oral dose of an iron binding compound in an amount effective to inhibit intestinal iron absorption and to reduce body iron stores to a near-iron deficiency level corresponding to a serum ferritin level less than about 40 ng/ml and an iron saturation index less than about 15%.
Dependencies are inferred from the claim text.