A compound of the formula ##STR16## or a pharmaceutically acceptable salt thereof;
- wherein Ar is phenyl;
- R.sup.1 and R.sup.16 are each independently hydrogen, (C.sub.1 -C.sub.6)alkyl, (trifluoromethyl).sub.2 (C.sub.1 -C.sub.6)alkyl, perfluoro(C.sub.1 -C.sub.6)alkyl, perfluoro(C.sub.1 -C.sub.6)alkyl(C.sub.1 -C.sub.6)alkyl, difluoromethoxy, trifluoromethoxy, (C.sub.3 -C.sub.7)cycloalkyl (C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.10)aryloxy(C.sub.1 -C.sub.6)alkyl or (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkoxy(C.sub.1 -C.sub.6)alkyl;
- R.sup.2 is (C.sub.1 -C.sub.6)alkyl or (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl optionally substituted by hydroxy, amino, halo, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, (trifluoromethyl).sub.2 (C.sub.1 -C.sub.6)alkyl, perfluoro(C.sub.1 -C.sub.6)alkyl, perfluoro(C.sub.1 -C.sub.6)alkyl(C.sub.1 -C.sub.6)alkyl, difluoromethoxy, trifluoromethoxy, carboxy or carboxamoyl;
- R.sup.3 is (C.sub.1 -C.sub.6)alkyl or (C.sub.6 -C.sub.10)aryl;
- R.sup.4 is hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, (C.sub.3 -C.sub.7)cycloalkyl(C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkylsulfonyl, (C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10)aryloxy, (C.sub.6 -C.sub.10)arylsulfonyl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkoxy, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkylsulfonyl, N-phthalimido, (C.sub.6 -C.sub.10)arylNHCO, (C.sub.6 -C.sub.10)arylNHSO.sub.2, R.sup.7 OOC, R.sup.7 R.sup.8 NCO, R.sup.7 R.sup.8 NSO.sub.2 wherein R.sup.7 and R.sup.8 are each independently hydrogen, (C.sub.1 -C.sub.6)alkyl or (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl;
- (C.sub.1 -C.sub.6)alkyl CR.sup.9 R.sup.10, (C.sub.6 -C.sub.10)aryl CR.sup.9 R.sup.10, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkylCR.sup.9 R.sup.10 wherein R.sup.9 and R.sup.10 are each independently fluoro, (C.sub.1 -C.sub.6)alkyl or (C.sub.1 -C.sub.6)alkoxy;
- or R.sup.9 and R.sup.10 may be taken together with the carbon to which they are attached to form a group of the formula ##STR17## wherein a is 0, 1 or 2;
- b is 0 or 1;
- c is 1, 2, or 3;
- d is 0 or 1;
- and
- e is 0, 1 or 2;
- R.sup.5 and R.sup.6 are each independently hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, halo, (trifluoromethyl).sub.2 (C.sub.1 -C.sub.6)alkyl, perfluoro(C.sub.1 -C.sub.6)alkyl, perfluoro(C.sub.1 -C.sub.6)alkyl(C.sub.1 -C.sub.6)alkyl, difluoromethoxy, trifluoromethoxy, (C.sub.1 -C.sub.6)alkylthio, (C.sub.1 -C.sub.6)alkylsulfinyl or (C.sub.1 -C.sub.6)alkylsulfonyl;
- or R.sup.1 and R.sup.16 may be taken together with the carbon to which they are attached to form a (C.sub.3 -C.sub.7)cycloalkyl group optionally substituted by (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl, (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl or (C.sub.6 -C.sub.10)aryloxy;
- or R.sup.5 and R.sup.6, when attached to adjacent carbon positions, may be taken together to form a group of the formula ##STR18## wherein the broken lines represent optional double bonds;
- h is 1 or 2;
- f and g are each independently 0, 1 or 2;
- Y and Z are each independently CH.sub.2, O, CO, SO.sub.2, CH.sub.2 CH.sub.2, CH.sub.2 O, CH.sub.2 S, CH.sub.2 NH, CH.sub.2 CO, CH.sub.2 SO.sub.2, NHCO or NHSO.sub.2 ;
- and
- R.sup.11 is hydrogen, halo, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, (trifluoromethyl).sub.2 (C.sub.1 -C.sub.6)alkyl, perfluoro(C.sub.1 -C.sub.6)alkyl, perfluoro(C.sub.1 -C.sub.6)alkyl(C.sub.1 -C.sub.6)alkyl, difluoromethoxy or trifluoromethoxy;
- with the proviso that when either a or e is 0, the other must be 1;
- with the proviso that when b and d are 1, the sum of a, c and e cannot be 5, 6 or 7;
- with the proviso that when b and d are 0, the sum of a, c and e cannot be 7;
- with the proviso that the methylene carbon attached to the phosphorus atom must be attached to a carbon atom of the Ar ring;
- and
- with the proviso that R.sup.5 and R.sup.6 must be attached to carbon atoms of the Ar ring.