Combination containing growth factors and polyelectrolytes
AssigneeMerck Patent Gesellschaft mit
InventorBerthold Nies
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Abstract
The invention relates to active substance combinations which consist of at least one polypeptide with the biological action of fibroblast growth factors and of at least one cationic polyelectrolyte. These combinations permit improved dosage of the FGF activity.
Claims14
A pharmaceutical composition, consisting essentially of 0.1 ng/ml-500 .mu.g/ml of an FGF peptide and a cationic polyelectrolyte, wherein, when the composition is in solution, the cationic polyelectrolyte is bioavailable in an amount effective to decrease non-specific binding of the FGF peptide.
A pharmaceutical composition, consisting essentially of 0.1 ng/ml-500 .mu.g/ml of FGF peptide and a cationic polyelectrolyte
- wherein the cationic polyelectrolyte is bioavailable in an amount effective to decrease non-specific binding of the FGF peptide, and
- wherein, when the composition is in solution, the cationic polyelectrolyte does not increase the viscosity of the solution.
A web material, comprising a dried pharmaceutical composition, consisting essentially of 0.1 ng/ml-500 .mu.g/ml of an FGF peptide and a cationic polyelectrolyte, wherein, when the composition is in solution, the cationic polyelectrolyte is bioavailable in an amount effective to decrease non-specific binding of the FGF peptide.
A wound dressing gauze, consisting essentially of a dried pharmaceutical composition, comprising 0.1 ng/ml-500 .mu.g/ml of an FGF peptide and a cationic polyelectrolyte, wherein, when the composition is in solution, the cationic polyelectrolyte is bioavailable in an amount effective to decrease non-specific binding of the FGF peptide.
Dependencies are inferred from the claim text.