Methods and compositions for the prophylactic and/or therapeutic treatment of organ hypofunction
AssigneeTakeda Chemical Industries, Ltd.
InventorsToshifumi Watanabe, Mitsuhiro Wakimasu, Chieko Kitada
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Abstract
Compounds having antagonistic activity on endothelin receptors can be effectively used for prophylaxis and/or treatment of hypofunction of organs which occurs in their surgery or transplant.
Claims6
A method of treating organ hypofunction in a host, said hypofunction being caused by ischemia due to surgery on said organ, said method comprising administering to said host an organ hypofunction treatment effective amount of cyclo(D-Asp-AspR1)-Asp-D-Thg(2)-Leu-D-Trp) or a pharmaceutically acceptable salt thereof, wherein AspR1) is aspartic acid .beta.-4-phenylpiperazineamide and Thg(2) is 2-(2-thienyl)glycine and wherein said organ is selected from the group consisting of liver and kidney.
A method of treating organ hypofunction in a host, said hypofunction being caused by ischemia due to surgery on said organ, said method comprising administering to said host an organ hypofunction treatment effective amount of disodium salt cyclo(D-Asp-AspR1)-Asp-D-Thg(2)-Leu-D-Trp), in which AspR1) is aspartic acid .beta.-4-phenylpiperazineamide and Thg(2) is 2-(2-thienyl)glycine and wherein said organ is selected from the group consisting of liver and kidney.
Dependencies are inferred from the claim text.