5-lipoxygenase-activating protein II
AssigneeHuman Genome Sciences, Inc.
InventorsReiner L. Gentz, Robert D. Fleischmann
Life of this patent
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Abstract
Disclosed is a human FLAP II polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Further, antagonists against such polypeptide are disclosed. Such antagonists may be used for therapeutic proposes, for example, for treating inflamation, bronchial asthma and may also be used as gastric cytoprotective agents and to treat human glomerulonephritis. Diagnostic assays for identifying mutations in nucleic acid sequences encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
Claims15
An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:
- (a) the amino acid sequence of residues 1 to 147 of SEQ ID NO:2;
- and
- (b) the amino acid sequence of residues 2 to 147 of SEQ ID NO:2.
An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:
- (a) the amino acid sequence of the full-length polypeptide encoded by the human cDNA contained in ATCC Deposit No. 75771;
- (b) the amino acid sequence of the full-length polypeptide encoded by the human cDNA contained in ATCC Deposit No. 75771, excluding the N-terminal methionine;
- and
- (c) the amino acid sequence of a mature polypeptide encoded by the human cDNA contained in ATCC Deposit No. 75771.
Dependencies are inferred from the claim text.