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US 6,146,886 AGranted
RNA polymerase III-based expression of therapeutic RNAs
AssigneeRibozyme Pharmaceuticals, Inc.
InventorJames D. Thompson
Life of this patent
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Abstract
A transcribed non-naturally occuring RNA molecule comprising a desired RNA molecule, wherein the 3' region of the RNA is able to base-pair with at least 8 bases at the 5' terminus of the same RNA molecule.
Claims21
A transcribed non-naturally occurring RNA molecule, comprising
- a desired RNA portion, wherein said non-naturally occurring RNA molecule comprises an intramolecular stem formed by base-pairing interactions between a 3' region and 5' complementary nucleotides in said RNA, wherein said intramolecular stem comprises at least 8 base pairs;
- wherein said desired RNA portion is present between the 3' region and the 5' complementary nucleotides;
- and
- wherein said desired RNA portion is selected from the group consisting of antisense RNA, decoy RNA enzymatic RNA, agonist RNA and antagonist RNA.
1 more element
Dependencies are inferred from the claim text.