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US 6,146,869 AGranted
Polypeptides having phospholipase B activity and nucleic acids encoding same
AssigneeNovo Nordisk Biotech, Inc.
InventorsPaul Harris, Kimberly M. Brown
Life of this patent
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Abstract
The present invention relates to isolated polypeptides having phospholipase B activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
Claims14
An isolated polypeptide having phospholipase B activity, selected from the group consisting of:
- (a) a polypeptide having an amino acid sequence which has at least 65% identity with amino acids 20 to 464 for the mature polypeptide of SEQ ID NO. 2;
- (b) a polypeptide which is encoded by a nucleic acid sequence which hybridizes under low stringency conditions with (i) nucleotides 568 to 2045 of SEQ ID NO. 1, (ii) the cDNA sequence corresponding to nucleotides 568 to 2045 of SEQ ID NO. 1, (iii) a subsequence of (i) or (ii) of at least 100 nucleotides, or (iv) a complementary strand of (i), (ii), or (iii);
- (c) an allelic variant of (a) or (b);
- and
- (d) a fragment of (a), (b), or (c) that has phospholipase B activity.
2 more elements
Dependencies are inferred from the claim text.