Staphylococcus aureus 3-hydroxyacyl-CoA dehydrogenase
AssigneeSmithKline Beecham Corporation
InventorsLeslie Marie Palmer, Michael A Lonetto, Richard O Nicholas, Robert L Deresiewicz, Julie M Pratt, John E Hodgson, David T Beattie, Adrian M Lowe
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Abstract
The invention provides hcd polypeptides and polynucleotides encoding Staphylococcus aureus 3-hydroxyacyl-CoA dehydrogenase (hcd) polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing hod polypeptides to screen for antibacterial compounds.
Claims18
An isolated polynucleotide fragment comprising a first polynucleotide or the full complement of the entire length of the first polynucleotide, wherein the first polynucleotide comprises the nucleic acid sequence set forth in SEQ ID NO:1.
An isolated polynucleotide fragment comprising a first polynucleotide or the full complement of the entire length of the first polynucleotide, wherein the first polynucleotide encodes a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:2.
An isolated polynucleotide fragment comprising a first polynucleotide or the full complement of the entire length of the first polynucleotide, wherein the first polynucleotide encodes a polypeptide consisting of the amino aid sequence set forth in SEQ ID NO:2.
An isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO:2.
An isolated fusion polypeptide comprising the amino acid sequence set for in SEQ ID NO:2.
Dependencies are inferred from the claim text.