Protein kinase molecules and uses therefor
AssigneeMillennium Pharmaceuticals, Inc.
InventorSusan Acton
Life of this patent
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Abstract
The invention provides isolated nucleic acid molecules, designated CSAPK-2 nucleic acid molecules, which encode novel cardiovascular system associated protein kinases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CSAPK-2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for producing CSAPK-2 polypeptides.
Claims72
An isolated nucleic acid molecule comprising the nucleotide sequence set forth in SEQ ID NO:4 or a complement thereof.
An isolated nucleic acid molecule comprising the nucleotide sequence set forth in SEQ ID NO:6 or a complement thereof.
An isolated nucleic acid molecule consisting of the nucleotide sequence set forth in SEQ ID NO:4 or a complement thereof.
An isolated nucleic acid molecule consisting of the nucleotide sequence set forth in SEQ ID NO:6 or a complement thereof.
An isolated nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:5, or a complement thereof.
An isolated nucleic acid molecule which encodes a polypeptide consisting of the amino acid sequence set forth in SEQ ID NO:5, or a complement thereof.
An isolated nucleic acid molecule comprising the nucleotide sequence contained in the plasmid deposited with ATCC.RTM. as Accession Number 203306 or a complement thereof.
An isolated nucleic acid molecule comprising a nucleotide sequence which is at least 90% identical to the nucleotide sequence of SEQ ID NO:4 over it's entire length, or a complement thereof.
An isolated nucleic acid molecule consisting of a nucleotide sequence which is at least 90% identical to the nucleotide sequence of SEQ ID NO:4 or it's entire length, or a complement thereof.
A recombinant host cell comprising a nucleic acid molecule comprising the nucleotide sequence set forth in SEQ ID NO:4 operatively linked to a recombinant regulatory sequence.
A recombinant host cell comprising a nucleic acid molecule comprising the nucleotide sequence set forth in SEQ ID NO:6 operatively linked to a recombinant regulatory sequence.
A recombinant host cell comprising a nucleic acid molecule consisting of the nucleotide sequence set forth in SEQ ID NO:4 operatively linked to a recombinant regulatory sequence.
A recombinant host cell comprising a nucleic acid molecule consisting of the nucleotide sequence set forth in SEQ ID NO:6 operatively linked to a recombinant regulatory sequence.
A recombinant host cell comprising a nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:5, operatively linked to a recombinant regulatory sequence.
A recombinant host cell comprising a nucleic acid molecule which encodes a polypeptide consisting of the amino acid sequence set forth in SEQ ID NO:5, operatively linked to a recombinant regulatory sequence.
A recombinant host cell comprising a nucleic acid molecule comprising the nucleotide sequence contained in the plasmid deposited with ATCC.RTM. as Accession Number 203306, operatively linked to a recombinant regulatory sequence.
A recombinant host cell comprising a nucleic acid molecule comprising a nucleotide sequence which is at least 90% identical to the nucleotide sequence of SEQ ID NO:4 over it's entire length, operatively linked to a recombinant regulatory sequence.
A recombinant host cell comprising a nucleic acid molecule consisting of a nucleotide sequence which is at least 90% identical to the nucleotide sequence of SEQ ID NO:4 over it's entire length, operatively linked to a recombinant regulatory sequence.
Dependencies are inferred from the claim text.