Cellular models for diabetes and other diseases associated with mitochondrial defects
AssigneeMitoKor
InventorsRobert E. Davis, Corinna Herrnstadt
Life of this patent
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Abstract
The present invention relates to genetic mutations in mitochondrial genes that segregate with diabetes mellitus. The invention provides methods for detecting such mutations, as a diagnostic for diabetes mellitus, either before or after the onset of clinical symptoms. Examples of specific mutations in the mitochondrial ATP synthase 8/6 gene and tRNA lysine gene are given. The invention also provides treatments for dysfunctions due to mitochondrial genes that segregate with diabetes mellitus. Cybrid cell lines are described which are useful as model systems for the study of the mitochondrial metabolic disorders that are associated with diabetes mellitus, and for identifying therapeutic compounds and treatments for this disease.
Claims6
A cybrid cell line, comprising:
- cultured cells having genomic and mitochondrial nucleic acids of different biological origins, wherein said mitochondrial or genomic nucleic acid is derived from an individual exhibiting symptoms of late onset diabetes mellitus or at risk for developing symptoms for late onset diabetes mellitus.
Dependencies are inferred from the claim text.