Process for modifying surfaces using the reaction product of a water-insoluble polymer and a polyalkylene imine
AssigneeTerumo Cardiovascular Systems Corporation
InventorsDavid F. Wirt, Larry M. Sirvio
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Abstract
A process for modifying a surface of an article that includes treating a surface with a solution that includes an organic solvent, and the reaction product of a substantially water insoluble polymer and a polyalkylene imine to form a modified surface.
Claims35
A process for modifying a surface of an article comprising:
- forming a solution comprising
- (a) an organic solvent, and
- (b) the reaction product of a substantially water insoluble polymer and a polyalkylene imine;
- and
- forming a coating on the surface of the article with the solution to form a modified surface.
A process for modifying a surface of an article comprising:
- treating a surface with a solution comprising
- a) an organic solvent, and
- (b) the reaction product of a substantially water insoluble polymer and a polyalkylene imine to form a modified surface, wherein said substantially water insoluble polymer comprises the reaction product of isooctyl acrylate and methyl methacrylate.
A process for modifying a surface of an article comprising:
- treating a surface with a solution comprising
- (a) an organic solvent, and
- (b) the reaction product of a substantially water insoluble polymer and a polyalkylene imine to form a modified surface, wherein said substantially water insoluble polymer comprises the reaction product of an alkyl methacrylate, an alkyl acrylate, and N-vinyl pyrrolidone.
A process for modifying a surface of an article comprising:
- treating a surface with a solution comprising
- (a) an organic solvent, and
- (b) the reaction product of a substantially water insoluble polymer and a polyalkylene imine to form a modified surface, wherein said substantially water insoluble polymer comprises the reaction product of an alkyl acrylate, an alkyl methacrylate, and a hydroxy alkyl methacrylate.
An article comprising a substrate having a modified surface comprising the reaction product of a substantially water insoluble polymer and a polyalkylene imine, wherein said substantially water insoluble polymer comprises the reaction product of isooctyl acrylate and methyl methacrylate.
An article comprising a substrate having a modified surface comprising the reaction product of a substantially water insoluble polymer and a polyalkylene imine, wherein said substantially water insoluble polymer comprises the reaction product of an alkyl methacrylate, an alkyl acrylate, and N-vinyl pyrrolidone.
An article comprising a substrate having a modified surface comprising the reaction product of a substantially water insoluble polymer and a polyalkylene imine, wherein said substantially water insoluble polymer comprises the reaction product of an alkyl acrylate, an alkyl methacrylate, and a hydroxy alkyl methacrylate.
An article comprising a substrate having a modified surface comprising:
- (a) a primer comprising the reaction product of (i) a substantially water insoluble polymer comprising the reaction product of an alkyl acrylate, an alkyl methacrylate, and N-vinyl pyrrolidone and (ii) polyethylene imine;
- and
- (b) a biologically active agent comprising heparin covalently bound to said primer,
- wherein the article is formed by a process comprising
- forming a solution comprising the reaction product of (i) the substantially water insoluble polymer comprising the reaction product of the alkyl acrylate, the alkyl methacrylate, and the N-vinyl pyrrolidone and (ii) the polyethylene imine;
- and
- coating the surface of the article with the solution to form a modified surface.
Dependencies are inferred from the claim text.