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US 6,146,664 AGranted
Stable topical ascorbic acid compositions
AssigneeShaklee Corporation
InventorMukhtar Siddiqui
Life of this patent
Estimating the term…
Abstract
An ascorbic acid (Vitamin C) composition in a nonaqueous or substantially anhydrous silicone vehicle has superior stability. Particulate ascorbic acid is substantially insoluble in the disclosed polyorganosiloxane vehicles, and the vehicle substantially excludes environmental oxygen. The ascorbic acid particles have surprisingly been found to have a high degree of bioavailability and effectiveness, for example in topical applications to reduce wrinkles and increase collagen growth and elasticity.
Claims24
A topical composition, comprising:
- particulate ascorbic acid in an amount of 0.1-40 % by weight;
- and
- a nonaqueous silicone carrier, in an amount of 50-99.9% by weight, wherein the nonaqueous silicone carrier is in a sufficient amount to suspend an effective amount of the particulate ascorbic acid, the particulate ascorbic acid is substantially insoluble in the silicone carrier, and the particulate ascorbic acid consists essentially of anhydrous solid ascorbic acid particles having a particle size of less than about 20 .mu.m,
- wherein the composition comprises less than 10% water by weight.
1 more element
A composition comprising:
- a silicone vehicle, in an amount of 50-80% by weight, which is substantially free of water or atmospheric oxygen, and in which ascorbic acid is substantially insoluble;
- and
- particulate anhydrous ascorbic acid, in an amount of 0.1-40% by weight, having a particle size of less than about 12.5 .mu.m, and which is substantially insoluble in the silicone vehicle, wherein the composition is nonaqueous and stable to oxidation of ascorbic acid by atmospheric oxygen;
- and the composition comprises less than 10% water by weight.
1 more element
Dependencies are inferred from the claim text.