Stabilized nanoparticles which may be filtered under sterile conditions
AssigneeRhone-Poulenc Rorer S.A.
InventorsMarie-Christine Bissery, Michel Laborie, Joel Vacus, Thierry Verrecchia
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Abstract
This invention relates to stabilized nanoparticles which may be filtered under sterile conditions, comprising at least one hydrophobic, water-insoluble and non-water-dispersible polymer or copolymer (and optionally an active principle) which is emulsified in an aqueous solution or suspension comprising a phospholipid and a bile salt.
Claims20
Stabilized nanoparticles which may be filtered under sterile conditions through a filter having a porosity of 220 nm, comprising a hydrophobic, water-insoluble polymer and copolymer suspended in an aqueous solution or dispersion comprising a phospholipid and a bile salt, wherein said hydrophobic, water-insoluble polymer or copolymer cannot be dispersed in water without the aid of a dispersing agent.
A process for the preparation of stabilized nanoparticles, said process comprising:
- preparing an aqueous solution or dispersion comprising a phospholipid and a bile salt,
- adding to the aqueous solution of dispersion an immiscible organic phase including, in an organic solvent, a hydrophobic, water-insoluble polymer or copolymer and, optionally, an active principle, to obtain a mixture, wherein said hydrophobic, water-insoluble polymer or copolymer cannot be dispersed without the aid of a dispersing agent,
- pre-emulsifying and the homogenizing the mixture,
- evaporating the organic solvent from said mixture to obtain a suspension, and
- the filtering and optionally freeze-drying the suspension obtained.
An emulsion comprising a hydrophobic, water-insoluble polymer or copolymer emulsified in an aqueous solution or dispersion comprising a phospholipid and a bile salt, wherein said hydrophobic, water-insoluble polymer or copolymer cannot be dispersed without the aid of a dispersing agent.
A process for the preparation of an emulsion, said process comprising:
- preparing an aqueous solution or dispersion comprising a phospholipid and a bile salt,
- adding to the aqueous solution or dispersion an immiscible organic phase including, in an organic solvent, a hydrophobic, water-insoluble polymer or copolymer to obtain a mixture, wherein said hydrophobic, water-insoluble polymer or copolymer cannot be dispersed without the aid of a dispersing agent, and
- pre-emulsifying and then homogenizing the mixture.
Dependencies are inferred from the claim text.